Fresh analysis indicates that people who stop using new GLP-1 drugs like Mounjaro or Wegovy may regain lost weight much more quickly than those who end conventional lifestyle programs.
Published data in a prominent medical journal demonstrates that while overweight individuals frequently drop substantial amounts of their total mass while on the medication, the mass comes back at an estimated rate of nearly a kilo each month once they quit.
"Users purchasing such medications need to be aware of the potential of rapid rebound weight gain when the medication is stopped," warns expert Dr. Susan Jebb.
This pace of regain means a return to original weight in about one and a half years.
Analyzing Treatments
The analysis, which reviewed 37 of studies involving thousands of participants, compared the outcomes of the injectable medications with other pills.
The team point out that people who lose weight through diet and exercise typically experience a more gradual creep back—approximately 100 grams monthly—once they finish.
Understanding the Fast Regain
Nutrition scientists suggest the way of the jabs is key to understanding the accelerated rebound.
These medications mimic a natural hormone called GLP-1, which moderates feelings of fullness.
"Long-term administration of the hormone levels several times higher than normal may cause the body to generate a reduced amount of its endogenous hormone, and could reduce sensitivity to its actions," noted Dr. Adam Collins, a nutrition specialist.
"Stopping of this medication means hunger is unsuppressed, making binge eating a significant risk."
An Ongoing Condition?
The NHS advise the injections for individuals with obesity-related medical conditions, alongside prescribed lifestyle changes.
A number of clinicians say that, given the likelihood of relapse, the treatment should be considered long-term.
This opinion is echoed by drug manufacturers, who state that the findings "underscore the persistent nature of excess weight," akin to managing diseases like diabetes.
User Experiences
People who have stopped the jabs describe a powerful resurgence of hunger.
"I experienced something that goes on and you become starving," recalled an individual.
The struggle is exacerbated if users have not adopted permanent lifestyle or habit changes during treatment.
Significant Use
Recent estimates suggest that a significant number of people in the UK have used these injections in the last 12 months, with interest continuing to grow.
- Use is greater among females compared to males.
- The middle-aged demographic shows the highest usage rates.
- A large proportion obtain the medications through private prescriptions rather than the NHS.
In conclusion, clinicians caution that while these medications are effective tools for weight loss, they are not a permanent solution and lasting health benefits relies on ongoing behavioural support.
